1. To realise real impact on young patients: improve their survival rate and reduce toxicity to restore young patients to full health after treatment.

2. To advance cutting-edge research that deepens our understanding of paediatric cancers.

3. To strengthen interdisciplinary collaboration and innovation in order to overcome the most pressing challenges in paediatric cancer research

4. To strengthen collaboration and the development of scientific capacity across Europe. The FKC calls for projects aim towards overcoming the structural lack of research dedicated to paediatric cancers by ensuring a recurring endowment that will be granted to the best European research projects every year. An additional ambition is to foster closer working ties between basic researchers and clinicians.

1. Early Phase Clinical Trials to evaluate innovative therapies for children and adolescents with cancer. These trials must be conducted and financed in at least 2 European countries over 3 years or less. We particularly welcome innovative clinical trial design approaches.

2. Translational Research Projects addressing childhood and adolescent cancers. We strongly encourage multidisciplinary or multi-institution collaborations that lead to the identification of novel targets of action, new therapies or more relevant disease models. We require a clear pathway to a clinical trial but we accept high-risk / high return proposals.

– A light application form or “Expression of interest”, reviewed by two independent reviewers based on the likelihood of (i) improving survival rate, (ii) improving quality of life during and after the treatments, (iii) improving our knowledge on cancer causes and treatment resistance and (iv) of resulting in a clinical trial.

– A full proposal, reviewed by two (translational) or three (clinical) independent reviewers that are experts in the field, and two panellists based on (i) their scientific excellence, (ii) the quality and efficiency of the implementation and (iii) the impact for patients (including societal / policy relevance and approaches to stakeholder engagement).